Marilyn Hardesty is an aging, terminally ill horror film icon who is determined to cheat death by having her mind transferred into the body of a younger woman. She has the means: in her late twenties, she inherited a biotech empire through a whirlwind courtship, marriage, and funeral. With Norman Baetz, her "personal assistant", and Dr. Laurence Fine, a brilliant, twisted neurobiologist, she pursues an obsession with immortality.

They entice three young women to Marilyn's remote estate through the lure of Reality TV prize money. Ulterior motives unfold. Dr. Fine's early experiments prowl the estate. The young women reach a grim realization: escape is the only means of survival. Can they evade Dr. Fine's cut and paste cybernetics? Will Marilyn achieve eternal life or drown in the fountain of youth?